Evaluating candidate agents of selective pressure for cystic fibrosis
نویسندگان
چکیده
منابع مشابه
Evaluating candidate agents of selective pressure for cystic fibrosis.
Cystic fibrosis is the most common lethal single-gene mutation in people of European descent, with a carrier frequency upwards of 2%. Based upon molecular research, resistances in the heterozygote to cholera and typhoid fever have been proposed to explain the persistence of the mutation. Using a population genetic model parameterized with historical demographic and epidemiological data, we show...
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In this research, we applied both supervised and unsupervised machine learning methodologies to spirometric data from patients with cystic fibrosis (CF). We developed an ensemble of neural networks to evaluate the severity of chronic CF within an individual, given the appropriate clinical input data, and a series of reference equations to describe the CF patient’s pulmonary function at differen...
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We used an oral topical antibiotic preparation to try and prevent oropharyngeal carriage of Pseudomonas aeruginosa in patients with cystic fibrosis. Ten of 15 patients treated with a two week course of intravenous ceftazidime together with a 90 day course of an antibiotic containing gel continued to carry P aeruginosa in the oropharynx.
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Background: Cystic fibrosis (CF) is the most common lethal genetic disorder of Cystic Fibrosis Trans-membrane Conductance (CFTR) Regulator gene mutations. We aimed to investigate common mutations in CF patients and to assess its possible relationship with clinical presentations. Materials and Methods: This cross sectional study was conducted on 36 CF patients who were referred to a tertiary ped...
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ژورنال
عنوان ژورنال: Journal of The Royal Society Interface
سال: 2006
ISSN: 1742-5689,1742-5662
DOI: 10.1098/rsif.2006.0154